| 書目名稱 | Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials | | 編輯 | Meinhard Kieser | | 視頻video | http://file.papertrans.cn/633/632206/632206.mp4 | | 概述 | Presents up-to-date methods for sample size calculation and recalculation in clinical trials.Offers recommendations for application of sample size calculation and recalculation in clinical trials, tak | | 叢書名稱 | Springer Series in Pharmaceutical Statistics | | 圖書封面 |  | | 描述 | .This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Appropriate calculation of the required sample size is crucial for the success of clinical trials. At the same time, a sample size that is too small or too large is problematic due to ethical, scientific, and economic reasons. Therefore, state-of-the art methods are required when planning clinical trials. ..Part I describes a general framework for deriving sample size calculation procedures. This enables an understanding of the common principles underlying the numerous methods presented in the following chapters. Part II addresses the fixed sample size design, where the required sample size is determined in the planning stage and is not changed afterwards. It covers sample size calculation methods for superiority, non-inferiority, and equivalence trials, as well as comparisons between two and more than two groups. A wide range of further topics is discussed, including sample size calculation for multiple comparisons, safety assessment, and multi-regional trials. There is often some uncertainty about the assumptions to be made when calculating the | | 出版日期 | Book 2020 | | 關(guān)鍵詞 | 62P10; Sample size; clinical trials; adaptive design; fixed sample size design; internal pilot study desi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-49528-2 | | isbn_softcover | 978-3-030-49530-5 | | isbn_ebook | 978-3-030-49528-2Series ISSN 2366-8695 Series E-ISSN 2366-8709 | | issn_series | 2366-8695 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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