| 書目名稱 | Metastasis of Prostate Cancer |
| 編輯 | Richard J. Ablin,Malcolm D. Mason |
| 視頻video | http://file.papertrans.cn/632/631757/631757.mp4 |
| 概述 | Brings together experts from the laboratory and the clinic.Highlights the key areas of active, current, translational research.Resource for physicians and/or and scientists involved in the study of pr |
| 叢書名稱 | Cancer Metastasis - Biology and Treatment |
| 圖書封面 |  |
| 描述 | Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferati |
| 出版日期 | Book 2007 |
| 關(guān)鍵詞 | bisphosphonates; cell; chemotherapy; drug design; gene therapy; metastasis; molecular biology; prostate can |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4020-5847-9 |
| isbn_softcover | 978-94-017-8152-7 |
| isbn_ebook | 978-1-4020-5847-9Series ISSN 1568-2102 Series E-ISSN 2215-1648 |
| issn_series | 1568-2102 |
| copyright | Springer Science+Business Media B.V. 2007 |
|Archiver|手機(jī)版|小黑屋|
派博傳思國際
( 京公網(wǎng)安備110108008328)
GMT+8, 2025-10-19 11:31
發(fā)表于 2025-3-21 18:26:47
