Titlebook: Metals and Genetics; Bibudhendra Sarkar Book 1999 Springer Science+Business Media New York 1999 DNA.biochemistry.gene expression.genes.gen

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Chromium(III) as a Male Preconception Carcinogen in Mice,f childhood cancers, including brain tumor, Wilm’ tumor of kidney, leukemia, hepatoblastoma, retinoblastoma and sarcoma in soft tissues (Savitz and Chen, 1990; Olsen et al., 1991; Bunin et al, 1992; Tomatis, 1994). Interpretations of some of these data have been controversial, particularly with rega

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DNA Cleavage vs. Cross-Linking Using Nickel Peptides,m, albumin is one of the principal scavengers of these ions, in part via the N-terminus which in the human protein begins with the sequence Asp-Ala-His (DAH) (Harford and Sarkar, 1997). Since the characterization of this site, the N-terminal XXH motif has been identified in a number of other peptide

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Copper-Dependent DNA Scission, 10-phenanthroline-copper complex ((OP).Cu.) or as the 1:1 complex (OP-Cu) linked to a targeting ligand with high affinity for a specific DNA sequence or structure (Sigman, .., 1993; Sigman, 1996). Since our discovery of this reaction in the late “70”s (Sigman .., 1979), our laboratory has been inte

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Modulation of Glucocorticoid Signaling and Leukocyte Activation by Transition Metals,aryotes, and transcriptionally regulated by a variety of metals, hormones, and developmental signals. They most certainly play a role in resistance to heavy metal toxicity, and have been postulated to mediate several roles important in metal homeostasis in eukaryotes (Kagi and Schaffer, 1988). They

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,Yeast Mitochondrial Iron Metabolism and the Pathophysiology of Friedreich’s Ataxia,chemically — the ease at which it can gain or lose electrons- also makes iron potentially toxic. The toxicity of iron results from its ability to reduce molecular oxygen. A complete reduction of molecular oxygen results in the formation of H.O which is not dangerous. Incomplete reduction of oxygen l

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The Copper-Transporting ATpase Defective in Wilson Disease,rform different functions. Between them, they play a role in controlling copper levels in cells, providing for copper essential for number of enzymes, while preventing the accumulation of toxic levels of copper in cells. The genes for Menkes disease (designated .and Wilson disease (designated .were

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Badal K. Mandai,Bhaja K. Biswas,Ratan K. Dhar,Tarit Roy Chowdhury,Gautam Samanta,Gautam K. Basu,Chitest available scientific evidence.Provides detailed diagnost.Radiation Oncology: An Evidence-Based Approach (ROEBA) is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions on the basis of the best available scientific evid

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Andreas Kortenkampest available scientific evidence.Provides detailed diagnost.Radiation Oncology: An Evidence-Based Approach (ROEBA) is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions on the basis of the best available scientific evid