Titlebook: Metallointercalators; Synthesis and Techni Janice Aldrich-Wright Book 2011 Springer-Verlag/Wien 2011 Biomolecular drug design.Inorganic Che

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978-3-7091-1669-2Springer-Verlag/Wien 2011

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,Platinum(II) Intercalating Complexes Based on 2,2′:6′,2″-Terpyridine, caused considerable interest in other platinum complexes, particularly metallointercalators as it is believed these complexes could display a different spectrum of anticancer activity due to their different mode of binding [2].

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Introduction to Nuclear Magnetic Resonance,range of applications in various fields of research [1,2]. Of all the analytical techniques in chemistry, NMR has been proven to be superior and extremely useful for the characterisation of complex mixtures, biomolecular structures and dynamics, molecular interactions and aggregations.

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Target Biological Structures: The Cell, Organelles, DNA and RNA,potential targets for therapeutics. Water, inorganic ions and a large array of relatively small organic molecules (e.g., sugars, vitamins and fatty acids) account for approximately 80% of living matter, with water being the most abundant. Macromolecules such as proteins, polysaccharides, ribonucleic

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Ruthenium Polypyridyl Metallointercalators,rea of research, at the junction between biology and chemistry, is a challenge, as the fundamental principles by which DNA discriminates are not well understood. Investigating the biological functions of DNA necessitates probing interactions at the molecular level. As a result, there have been exten

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The Synthesis of Platinum(II) Intercalators,essential to gain some understanding of the mechanisms of drug action, and to determine which structural characteristics influence the pharmacological properties. Of particular interest are the interactions between anticancer agents and DNA, as DNA is considered to be the major cellular target for a