Titlebook: Metabolic Compartmentation in the Brain; R. Balázs,J. E. Cremer Textbook 1973Latest edition Macmillan Publishers Limited 1973 brain.medici

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Biochemical Consequences of Compartmentation of Glutamate and Associated Metaboliteshe course of these reactions in plant and animal tissues. One of the early attempts at the calculation of the ‘turnover rate’ from experiments with the use of a labelling agent was that of Zilversmit . (1943). The turnover rate was defined as the amount of the substance renewed per unit of time by i

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The Metabolic Compartmentation of Brain Monoaminese (5HT) is that it seems to be involved in almost every aspect of the synthesis, storage, release, regulation and metabolism of these substances. My whole theme will be to suggest that compartmentation of the brain monoamines at the cellular and subcellular level is the key to the mechanism by which

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Compartmentation and the Metabolism of γ-Aminobutyratect as a general inhibitory transmitter (Curtis and Watkins, 1965; Dreifuss ., 1969). At the same time GABA is an intermediate in the extension of the tricarboxylic acid cycle which involves the oxidation of .-oxoglutarate to succinate through glutamate, GABA and succinic semialdehyde (cf. Roberts an

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Glutamate Compartmentation in Developing Cat Braining changes in size and turnover rate of the metabolic pools. Further, it was also thought possible that these metabolic changes with ontogenesis would correlate with morphophysiological development. Such correlations might then permit extrapolation as to where these pools were located and possibly

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Compartmentation of Tricarboxylic Acid Cycle Intermediates and Related Metaboliteste metabolism (Lajtha ., 1960). This was further substantiated by the intra-carotid infusion of [.N]ammonia or [.C]bicarbonate (Berl ., 1962.,.). The specific radioactivity was found to be highest in glutamine, suggesting that glutamine was synthesized from an extremely active glutamate pool of rela