Titlebook: Messenger RNA Therapeutics; Stefan Jurga,Jan Barciszewski Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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Messenger RNA Therapeutics: Start of a New Era in Medicine,ses of RNA-based therapeutics. Among these, mRNA-based therapy is centered on producing proteins within the cells to supplant deficient or abnormal proteins and in vaccination to a target pathogen. The potential of mRNA therapeutics is evident from the two major mRNA vaccines approved for COVID-19:

鞏固

Hospital-Based RNA Therapeutics,e mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical-grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible a

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SARS-COV-2 and Other mRNA Vaccines, for the prevention of SARS-COV-2 disease following unprecedented speed of development through to emergency use licensure in around three hundred days from virus sequence availability. Case studies of three SARS-COV-2 mRNA vaccines for which field clinical efficacy data are available are examined an

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Synthetic mRNA Gene Therapies and Hepatotropic Non-viral Vectors for the Treatment of Chronic HBV Ience of HBV-associated liver cancer and cirrhosis. Currently, there is no cure for chronic HBV infection, and novel therapeutic approaches, including gene editing and epigenome engineering, are being investigated. Although promising, the liver-specific delivery, expression and safety profile of thes

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,Preparation of Synthetic mRNAs—Overview and Considerations,afe. The central advantage of the successful use of synthetic mRNA as a vaccine hinge on being able to rapidly manufacture the mRNA molecules. The synthetic mRNA is prepared in vitro via a cell-free enzymatic process. The aim of this chapter is to provide an overview of the enzymatic mRNA synthesis

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In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of Twenty-First Century:an efficient delivery system, the host cell ribosomes will be recruited to translate and produce the corresponding desired proteins. Nowadays, about 20?years after the first report as for the use of IVT-mRNA, this technology has all the spotlight on it, due to the recently produced vaccines against