Titlebook: Meningococcal Vaccines; Methods and Protocol Andrew J. Pollard,Martin C.J. Maiden Book 2001 Springer Science+Business Media New York 2001 i

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Construction of porA Mutants,ther one being the PorB or class 2/3 protein. It folds into a 16-stranded β-barrel structure, which is now well-established for bacterial porins, in which seven loops are exposed at the cell surface and the remaining one forms the constriction of the pore (.,.). There are approx 20 different serosub

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Construction of LPS Mutants, at both ends with diphosphoethanolamine, to which an oligosaccharide chain of up to 10 sugar residues is attached (.,.). It lacks a long repeating O-antigen side chain, as is typically found in many ., and is therefore also sometimes referred to as lipooligosaccharide or LOS. The oligosaccharide pa

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Recombinant Proteins in Vaccine Development,ntial of these proteins would be facilitated by the production of pure recombinant protein, free from other components of the . outer membrane. At present, the class 1 outer-membrane protein (OMP) is generally regarded as the most promising candidate. In this chapter, we describe four protocols invo

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Animal Models for Meningococcal Disease, bacteria with whole tissues and the humoral and cellular immune systems can be assessed. Animal-infection models are also of great importance for the assessment of the protective efficacy of existing and candidate vaccines. However, the relevance of these animal models to human disease and how well

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Leanne M. DeWinter,Anthony B. Schryversdem Ma?e mit dem Produktdesign besch?ftigen. Produkte, die in der Leistung, der Handhabung und in der Gestaltung exakt den Vorstellungen der Kunden entsprechen, bringen in der Vermarktung die notwendigen Wettbewerbsvorteile. Jedes Unternehmen m?chte mit derartigen Innovationen neue M?rkte erobern un