| 書目名稱 | Membrane Proteomics | | 副標(biāo)題 | Methods and Protocol | | 編輯 | Matthew J. Peirce,Robin Wait | | 視頻video | http://file.papertrans.cn/631/630390/630390.mp4 | | 概述 | Collects together in one volume the diverse practical approaches to analyzing membrane proteins.Includes both wet lab and in silico approaches.Includes protocols for the isolation of plasma membrane a | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | The membranes surrounding cells and organelles constitute their interface with the local environment. The functions of membrane proteins include cell/cell and cell/extracellular matrix recognition, the reception and transduction of extracellular signals, and the tra- port of proteins, solutes and water molecules. Abnormal membrane protein expression has profound biological effects and may, for example, underlie phenotypic and functional differences between normal and tumour cells. Moreover the accessibility, particularly of plasma proteins traversing the plasma membrane of cells, makes them of particular ut- ity to the therapeutic intervention in disease. Indeed, it is estimated that of all currently licensed pharmaceuticals, approximately 70% target proteins resident in the plasma m- brane. In theory, unbiased technologies such as proteomics have the power to de?ne patterns of membrane protein expression characteristic of distinct states of cellular development, differentiation or disease, and thereby identify novel markers of, or targets for intervention in, disease. However, although about 25% of open reading frames in fully sequenced genomes are estimated to encode integral mem | | 出版日期 | Book 2009 | | 關(guān)鍵詞 | Hydrophobicity; In silico; Lipid; Mammalian membrane proteins; Plant membrane proteins; Plasma and nuclea | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-60327-310-7 | | isbn_softcover | 978-1-61737-889-8 | | isbn_ebook | 978-1-60327-310-7Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2009 |
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