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Titlebook: Membrane Dynamics and Domains; Subcellular Biochemi Peter J. Quinn Book 2004 Springer Science+Business Media New York 2004 Lipid.biochemist

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書目名稱Membrane Dynamics and Domains
副標題Subcellular Biochemi
編輯Peter J. Quinn
視頻videohttp://file.papertrans.cn/631/630360/630360.mp4
叢書名稱Subcellular Biochemistry
圖書封面Titlebook: Membrane Dynamics and Domains; Subcellular Biochemi Peter J. Quinn Book 2004 Springer Science+Business Media New York 2004 Lipid.biochemist
描述The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif- ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc- tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes i
出版日期Book 2004
關(guān)鍵詞Lipid; biochemistry; cell biology; metabolism; regulation
版次1
doihttps://doi.org/10.1007/978-1-4757-5806-1
isbn_softcover978-1-4419-3447-5
isbn_ebook978-1-4757-5806-1Series ISSN 0306-0225 Series E-ISSN 2542-8810
issn_series 0306-0225
copyrightSpringer Science+Business Media New York 2004
The information of publication is updating

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nstream cardiology, these pioneers nonetheless persevered, proving the benefit of ‘‘state-of-the-art’’ balloon angioplasty compared with ‘‘state-of-t- art’’ thrombolytic therapy in a series of landmark trials p978-1-61737-903-1978-1-60327-497-5Series ISSN 2196-8969 Series E-ISSN 2196-8977
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Kamen S. Koumanov,Claude Wolf,Peter J. Quinnnstream cardiology, these pioneers nonetheless persevered, proving the benefit of ‘‘state-of-the-art’’ balloon angioplasty compared with ‘‘state-of-t- art’’ thrombolytic therapy in a series of landmark trials p978-1-61737-903-1978-1-60327-497-5Series ISSN 2196-8969 Series E-ISSN 2196-8977
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Ken Ritchie,Akihiro Kusuminstream cardiology, these pioneers nonetheless persevered, proving the benefit of ‘‘state-of-the-art’’ balloon angioplasty compared with ‘‘state-of-t- art’’ thrombolytic therapy in a series of landmark trials p978-1-61737-903-1978-1-60327-497-5Series ISSN 2196-8969 Series E-ISSN 2196-8977
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Rafts, Little Caves and Large Potholes: How Lipid Structure Interacts with Membrane Proteins to Creaed membrane from coated pits, and hence rapid endocytosis, is suggested to underlie the ability of highly ordered domains to establish stable secondary signalling systems required, for instance, in T cell receptor, insulin and neurotrophin signalling.
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Sphingomyelin and Cholesterol: From Membrane Biophysics and Rafts to Potential Medical Applicationsre indications that the raft LO phase domains are more tightly packed than the non-raft LO phase, possibly due to intermolecular hydrogen bonding involving sphingolipid and cholesterol. This also explains why the former are detergent-resistant membranes (DRM), while the non-raft LO phase domains are
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Membrane Targeting of Lipid Modified Signal Transduction Proteinsting. Clusters of basic residues can also synergize with the lipophilic group to promote membrane binding and targeting. The final destination of the modified protein is influenced by multiple factors, including the localization of the modifying enzymes, protein/protein interactions, and the lipid c
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