Titlebook: Mechanisms of Lymphocyte Activation and Immune Regulation VII; Molecular Determinan Sudhir Gupta,Alan Sher,Rafi Ahmed Book 1998 The Editor(

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Interleukin-4 Receptor Signalling Mechanisms and Their Biological Significance gene activation functions, IL-4 also acts as a co-stimulant of B and T cell growth. This is best seen with CD40 ligand, LPS or anti-IgM/IgD in B cells and with phorbol esters in T cells. IL-4 also acts to allow naive T cells to survive in tissue culture presumably by preventing apoptotic cell death

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