Titlebook: Mechanisms of Gene Regulation; Carsten Carlberg,Ferdinand Molnár Textbook 20141st edition Springer Science+Business Media Dordrecht 2014 c

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Chromatin Modifierscal processes in the context of development and cellular responses. The present understanding of the function of histone modifications is summarized in the histone code model..There are two pairs of chromatin modifying enzymes, each with antagonizing activity: histone acetylases and deacetylases and

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Genomic Imprintinghat insulate genes located in one chromatin domain from promiscuous regulation by enhancers or silencers in neighboring domains. The genome regulator CTCF has tens of thousands DNA-binding sites in human cells, many of which are located in intergenic regions, such as insulators. Most of these sites

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Chromatin Remodelingo access these sequences. This is controlled by histone modifications (see Chap.?8), DNA methylation (see Chaps.?9 and 10) and ATP-dependent chromatin remodeling. Chromatin remodeling factors are multi-protein complexes that use the energy of ATP hydrolysis to remodel or remove nucleosomes, in order

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Regulatory RNAs giving rise to thousands of non-coding RNAs (ncRNAs). Not all of these transcripts are functional, however, many ncRNAs have regulatory specificity. Micro RNAs (miRNAs) are small ncRNAs that post-transcriptionally regulate the expression of thousands of genes. After the identification of the exist

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Carsten Carlberg,Ferdinand Molnár the body. The pathways over which peripheral chemoreccptor signals are transmitted to respiratory muscles arc well established. However, the intracellular pathways that transmit hypoxic stimulus to gene activation are just being identified. Using anti-sense c-fos strategy, we have shown that c-fos

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