Titlebook: Mechanisms of Cancer Metastasis; Potential Therapeuti Kenneth V. Honn,William E. Powers,Bonnie F. Sloane Book 1986 Martinus Nijhoff Publish

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Multidrug Resistance and Metastasis,to a non-responsive disease. This non-response may extend to drugs or combination of drugs with which the patient had not been treated previously. The basis of this non-response is not well understood, although studies with model systems have provided insights to a number of possible factors. These

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Platelet-Tumor Cell Interactions as a Target for Antimetastatic Therapy,fined is the loss of contiguity between a tumor cell or clumps of tumor cells and the primary lesion followed by successful transfer to and growth at a site spatially separate from the original tumor. The overall process can be viewed as a series of sequential events representing complex interaction

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Mechanisms of Inhibition of Cancer Dissemination by Warfarin, drugs of this class limit tumor dissemination (1,2). However, variability in responsiveness of various tumor types to individual agents suggests that the mechanisms of drug action may be complex. The pattern of responsiveness of human tumor types to antithrombotic drugs remains undefined, neverthel

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Cancer Cell Procoagulants and their Possible Role in Metastasis,he first suggestion of a tumor cell thrombus dates back to 1936 when Warren and Gates (1) observed a “hyaline thrombus” associated with blood-borne Walker 256 cells. However, the early observations by Sumner Wood (2–5) showing that fibrin was associated with blood-borne malignant cells in the ear ch

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Interleukins, Lymphokines and Lymphoid Neoplasia,ut the body. The delineation of biological consequences of such invasion to the host is for the first time beginning to be understood on more than a phenomenologic basis. Recent studies with a wide variety of experimental tumor systems, as reported here and in the literature, have begun to elucidate

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The Use of Activated Macrophages for the Destruction of Heterogeneous Metastasis,lignancies are diagnosed, metastases have already been established in a variety of sites distant from the primary tumor, making selective excision or destruction by irradiation or chemotherapeutic agents extremely difficult. Exacerbating the problem of treating metastatic disease is the fact that ca

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