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Titlebook: Mechanism of Action of Antieukaryotic and Antiviral Compounds; Fred E. Hahn Book 1979 Springer-Verlag Berlin · Heidelberg 1979 Antibiotiku

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書(shū)目名稱(chēng)Mechanism of Action of Antieukaryotic and Antiviral Compounds
編輯Fred E. Hahn
視頻videohttp://file.papertrans.cn/629/628642/628642.mp4
叢書(shū)名稱(chēng)Antibiotics
圖書(shū)封面Titlebook: Mechanism of Action of Antieukaryotic and Antiviral Compounds;  Fred E. Hahn Book 1979 Springer-Verlag Berlin · Heidelberg 1979 Antibiotiku
描述When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan- isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto- myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti- cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti- microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequent
出版日期Book 1979
關(guān)鍵詞Antibiotikum; Antimykotikum; Chemotherapeutikum; Virostatikum; alkaloids; antibiotic; antibiotics; cancer; e
版次1
doihttps://doi.org/10.1007/978-3-642-46407-2
isbn_softcover978-3-642-46409-6
isbn_ebook978-3-642-46407-2
copyrightSpringer-Verlag Berlin · Heidelberg 1979
The information of publication is updating

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Antitumor Platinum Compounds,ion against Sarcoma 180 and Leukemia L1210 (. et al., 1969; . and . ., 1970), a viral-induced reticulum cell sarcoma in mice (., 1970), the Dunning ascitic leukemia, Walker 256 carcinosarcoma (. et al., 1970),and a DMBA-induced mammary carcinoma (., 1971) in rats.
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,9-β-D-Arabinofuranosyladenine (AraA),d by Parke, Davis and Company (British Patent No. 1,159,290) as an antibiotic produced by .. Chemical synthesis, initially achieved through the conversion of a xylonucleoside to araA (. et al., 1960; . et al., 1962), was subsequently accomplished on a larger scale by the condensation of 2,3,5-tri-O-
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8-Azaguanine,sed this inhibition. In 1949 . and . confirmed these findings when the analog inhibited multiplication of .. Subsequently, several investigators proved 8-azaguanine to be an inhibitor of the chick embryo (. et al., 1950), the Lucerne mosaic virus (., 1952), the . virus (., 1952), human glioblastomas
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Bleomycin,ntineoplastic antibiotic, bleomycin. ., the discoverer of bleomycin (. et al., 1966) has written several reviews dealing primarily with the chemistry, structure, in vitro, and in vivo studies of bleomycin (., 1975, 1976). Other articles dealing more specifically with the extracellular reaction betwe
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Diphtheria Toxin and Exotoxin A from ,,al toxins have been studied in greater depth, and new toxins have been discovered as well. As a result of the expanded interest and efforts there now exists a substantial and rapidly growing body of knowledge about the structures and activities of bacterial toxins from which one can begin to make me
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2-Hydroxy-3-Alkyl-1,4-Naphthoquinones,of the antimalarial drug quinine. Faced with entirely inadequate supplies of quinine coupled with the grim prospect of waging tropical warfare in some of the world’s worst malaria-infested regions, the Allied Powers instituted a comprehensive program of research in the chemotherapy of malaria. This
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Hydroxystilbamidine,midine, berenil, etc.), it shows strong activity against bacteria, protozoa, and fungi. It is clinically used in systemic mycosis, mainly North American blastomycosis, visceral leishmaniasis, and secondarily in prophylaxis and treatment of African trypanosomiasis, and in cases of malignancy, e.g., m
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,5-Iodo-2′-Deoxyuridine,e base analogs was initiated by . et al. (1945) and extended by . et al. (1949). The clinical potential of base analogs, whether halogenated or not, has been well recognized in chemotherapy. Furthermore, such compounds have proven to be powerful tools for elucidation of many intricate biochemical ev
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