Titlebook: Matrix Metalloproteinase Inhibitors in Cancer Therapy; Neil J. Clendeninn,Krzysztof Appelt Book 2001 Springer Science+Business Media New Y

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Biology and Regulation of the Matrix Metalloproteinases,nd in vivo by MMP overexpression or TIMP down-regulation, or they can be made less aggressive by MMP down-regulation, TIMP overexpression, or the addition of exogenous MMP inhibitors. Thus several MMPs have been shown to act as key agonists during tumor invasion, metastasis, and angiogenesis . In ad

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Substrate Specificity of MMPs,urth ligand and maintain inactive proenzyme. Another conserved sequence is the zinc binding motif HEXGHXXGXXH, in which three histidines bind to Zn.. Three dimensional structures of the catalytic domains of MMPs [MMP-1 ., MMP-3 ., MMP-7 ., MMP-8 ., MMP-14 .] indicate that the polypeptide fold of the

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Matrix Metalloproteinases in Cancer,ation. They can be carried to a new location, where a third invasive event must occur to extravasate into the parenchyma of the distant organ. Thus, proteolysis of basement membrane (BM) and extracellular matrix (ECM) components has been viewed as an essential step in tumor invasion and metastasis.

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Matrix Metalloproteinase Inhibitors,ns of MMPI in disease processes other than cancer. Other more comprehensive reviews have been published ., as has a recent volume compiling the proceedings of a recent conference dedicated to this topic ..