Titlebook: Marburg- and Ebolaviruses; From Ecosystems to M Elke Mühlberger,Lisa L. Hensley,Jonathan S. Towner Book 2017 Springer International Publish

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Ebola Virus Disease in Humans: Pathophysiology and Immunityoriety of ebolaviruses, particularly Ebola virus (EBOV), as prominent viral hemorrhagic fever agents, and the international concern regarding Ebola virus disease (EVD) outbreaks, very little is known about the pathophysiology of EVD in humans and, in particular, about the human immune correlates of

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Accelerating Vaccine Development During the 2013–2016 West African Ebola Virus Disease Outbreak slower and less coherent than was optimal given the scale and pace of the epidemic. Past experience with limited localized outbreaks, lack of licensed medical countermeasures, reluctance by first responders to direct scarce resources to clinical research, community resistance to outside interventio

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Filovirus Strategies to Escape Antiviral Responsesince filovirus replication can be efficiently blocked by interferon (IFN), filoviruses have evolved mechanisms to counteract both type I IFN induction and IFN response signaling pathways. Intriguingly, marburg- and ebolaviruses use different strategies to inhibit IFN signaling. This chapter also sum

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Mechanisms of Filovirus Entryant events required for filoviruses to enter into the endosomal compartment and fuse with vesicular membranes have been elucidated (Fig.?.). Here, we highlight the important steps that are required for productive entry of filoviruses into mammalian cells.

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Filovirus Structural Biology: The Molecules in the Machinet the fascinating findings of the last decade is the plurality of functions and structures that these polypeptides can adopt. Many of the encoded proteins can play multiple, distinct roles in the virus life cycle, although the mechanisms by which these functions are determined and controlled remain

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