Titlebook: Mammalian Transient Receptor Potential (TRP) Cation Channels; Volume II Bernd Nilius,Veit Flockerzi Book 2014 Springer International Publis

Forestall

書目名稱Mammalian Transient Receptor Potential (TRP) Cation Channels影響因子(影響力)




書目名稱Mammalian Transient Receptor Potential (TRP) Cation Channels影響因子(影響力)學科排名




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書目名稱Mammalian Transient Receptor Potential (TRP) Cation Channels讀者反饋學科排名

GLUT

Physiological Functions and Regulation of TRPC ChannelsPC channels generates distinct intracellular Ca. signals that regulate downstream signaling events and consequent cell functions. This requires localization of TRPC channels in specific plasma membrane microdomains and precise regulation of channel function which is coordinated by various scaffolding, trafficking, and regulatory proteins.

掃興

DEBT

0171-2004 s special cell sensors.Current findings in this field are cr?In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single

深淵

TRP Channels and Thermosensationrole as thermosensors in the somatosensory system and to understand the basis of their high thermal sensitivity. In this chapter, I provide a brief critical overview of current knowledge on the role of TRP channels in thermosensing and on the thermodynamic and molecular basis of their steep temperature dependence.

Neuralgia

High-Resolution Views of TRPV1 and Their Implications for the TRP Channel Superfamilybinding sites, and conformational changes related to channel pore gating. We also discuss some of the structures’ implications for the TRP channel family and a few of the many questions still left unanswered.

elucidate

Evolutionarily Conserved, Multitasking TRP Channels: Lessons from Worms and Fliesing proteins, and second, many functions and modes of activation of these channels are evolutionarily conserved, including some that were formerly thought to be unique to invertebrates, such as phototransduction. Thus, worms and flies offer the potential to decipher roles for mammalian TRPs, which would otherwise not be suspected.

buoyant

Structural Biology of TRP Channelsength structures of different TRP channel subfamilies, such as building homology models. Finally, we close by summarizing the outlook of the “holy grail” of understanding in atomic detail the diverse functions of TRP channels.

capsule

Book 2014gy of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Recep

不再流行

TRPs and Pain expression patterns, electrophysiological properties and the effects of channel deletion in transgenic animal models have produced a great deal of evidence linking these channels to transduction of noxious stimuli as well as signalling within the pain system.