Titlebook: Macropinocytosis; Functions and Mechan Cosimo Commisso Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license t

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KRASG12R-Independent Macropinocytosis in Pancreatic Cancers have underscored how little we understand about the activation and regulation of this metabolic process. Therefore, this review seeks to highlight the differences in macropinocytosis regulation in the two cellular subtypes while also highlighting the features that make the KRAS. mutant atypical.

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Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathwayser malignancy. Macropinocytic uptake can be induced in cancer cells by different stress stimuli, acting as an adaptive mechanism for the cells to resist stresses in the tumor milieu. Here, we review the cellular stresses that are known to promote macropinocytosis, as well as the underlying molecular mechanisms that drive this process.

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Macropinocytosis in Phagocyte Function and Immunityve macropinocytosis and its role in the maintenance of immunity. Functions previously attributed to macropinocytosis, including antigen presentation and immune surveillance, will be revisited in light of recent revelations and emerging concepts will be highlighted.

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astrophysics, and their border fields. It is devoted to the recording, summarizing, and indexing of the relevant publications throughout the world. Astronomy and Astrophysics Abstracts is prepared by a special department of the Astronomisches Rechen-Institut under the auspices of the International A

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Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathwaysytic vesicles known as macropinosomes. In addition to other functions, this uptake pathway supports cancer cell metabolism through the uptake of nutrients. Cells harboring oncogene or tumor suppressor mutations are known to display heightened macropinocytosis, which confers to the cancer cells the a

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The Amoebal Model for Macropinocytosisextended from the plasma membrane, then digest their contents and absorb the nutrients in the endo-lysosomal system. They use macropinocytosis for feeding, maintaining a high rate of fluid uptake that makes assay and experimentation easy. Mutants collected over the years identify cytoskeletal and si