Titlebook: Macromolecular Protein Complexes V; Structure and Functi J. Robin Harris,Jon Marles-Wright Book 2024 The Editor(s) (if applicable) and The

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The Copper Efflux Regulator (CueR),C-terminal effector-binding domain, CueR senses cytoplasmic copper ions to regulate the transcription of genes contributing to copper homeostasis, an essential process for survival of all cells. In this chapter, we review the regulatory roles of CueR in the model organism . and the mechanisms for Cu

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Telomere C-Strand Fill-In Machinery: New Insights into the Human CST-DNA Polymerase Alpha-Primase S the telomere “replisome.” The telomere replisome acts on a unique replicon at each chromosomal end of the telomeres, the 3’ DNA overhang. This telomere replication process is distinct from the replisome mechanism deployed to duplicate the human genome. The G-rich overhang is first extended before t

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Viral Genomic DNA Packaging Machinery, eukaryotic dsDNA viruses such as .. DNA packaging motor proteins represent excellent targets for antiviral therapy, with Letermovir, which binds . terminase, already licensed as an effective prophylaxis. In the realm of bacterial viruses, these DNA packaging motors comprise three protein constituen

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Human Transient Receptor Potential Ankyrin 1 Channel: Structure, Function, and Physiology,y nonneuronal tissues typically possessing barrier functions, such as the skin, joint synoviocytes, cornea, and the respiratory and intestinal tracts. Here, the primary role of TRPA1 is to detect potential danger stimuli that may threaten the tissue homeostasis and the health of the organism. The ab