Titlebook: Macromolecular Protein Complexes IV; Structure and Functi J. Robin Harris,Jon Marles-Wright Book 2022 The Editor(s) (if applicable) and The

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Ferritin-Like Proteins: A Conserved Core for a Myriad of Enzyme Complexes, permits a diverse set of reactions, and is central in a multitude of macromolecular enzyme complexes. Here, we emphasize this diversity through three members of the ferritin-like superfamily: the soluble methane monooxygenase, the class I ribonucleotide reductase and the aldehyde deformylating oxyg

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Still no Rest for the Reductases: Ribonucleotide Reductase (RNR) Structure and Function: An Update,cleotides to deoxyribonucleotides. This chapter primarily presents an overview of this multifaceted and complex enzyme, covering RNR’s role in enzymology, biochemistry, medicinal chemistry, and cell biology. It further focuses on RNR from mammals, whose interesting and often conflicting roles in hea

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On the Regulation of Mitosis by the Kinetochore, a Macromolecular Complex and Organising Hub of Eukh microtubules. Its function involves the coordinated action of more than 100 different proteins. The kinetochore acts as an organiser hub that establishes physical connections with microtubules and centromere-associated proteins and recruits central protein components of the spindle assembly checkp

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The Conformational Dynamics of Heterotrimeric G Proteins During GPCR-Mediated Activationons. G-protein-coupled receptors (GPCRs) are the major guanine nucleotide exchange factors (GEFs) that induce G proteins to release guanosine diphosphate and rapidly bind to guanosine triphosphate, resulting in G protein activation. G proteins undergo dynamic conformational changes during the activa

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Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisomen in some crucial cell wall remodeling processes such as cell division, elongation, or sporulation. FtsEX plays a double role by recruiting proteins to the divisome apparatus and by regulating lytic activity of the cell wall hydrolases required for daughter cell separation. Interestingly, FtsEX does

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Structure, Function, and Regulation of the Kainate Receptortatory branch of neurotransmission in the mammalian brain. Kainate receptors (KARs), a subfamily of the iGluRs, act as modulators of the neuronal circuitry by playing important roles at both the post- and presynaptic sites of specific neurons. The functional tetrameric receptors are formed by two di

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Structure and Function of Mycobacterial Arabinofuranosyltransferasesparticular. An important contributor to their evolutionary success is their unique cell envelope, which constitutes a quasi-impermeable barrier, protecting the microorganism from external threats, antibiotics included. The arabinofuranosyltransferases are a family of enzymes, unique to the . family