Titlebook: Machine Learning in Medicine; Ton J. Cleophas,Aeilko H. Zwinderman Textbook 2013 Springer Science+Business Media Dordrecht 2013 cluster an

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Partial Least Squares, add-up scores. But add-up scores do not account for the relative importance of the separate variables, their interactions and differences in units. Principal components analysis and partial least square analysis account all of that, but are virtually unused in clinical trials.

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Textbook 2013 further taken into account. In contrast, modern computer data files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required. This book was written as a hand-hold presentation accessible to clinicians, and as a must-read publication for those new to the methods.

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