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Titlebook: MHC Molecules: Expression, Assembly and Function; Robert G. Urban,Roman M. Chicz Book 1996 R.G. Landes Company and Chapman & Hall 1996 T c

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書目名稱MHC Molecules: Expression, Assembly and Function
編輯Robert G. Urban,Roman M. Chicz
視頻videohttp://file.papertrans.cn/621/620153/620153.mp4
圖書封面Titlebook: MHC Molecules: Expression, Assembly and Function;  Robert G. Urban,Roman M. Chicz Book 1996 R.G. Landes Company and Chapman & Hall 1996 T c
描述3 nant expression systems have been used to make MHC molecules con- taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide complexes and two superantigen complexes) have been reported. These advances have enabled us to study the atomic detail of antigen presentation and the general mechanisms behind peptide binding, and begin to construct models of T cell recognition. Another area of research which has exploded over the past five years has been the identification of MHC-associated peptides. There are several methods one can use to determine the sequence identity of MHC restricted peptides. Historically, the most successful technique, albeit crude and encumbered with serious limitations, has been the use of overlapping synthetic peptides and T cell clones. Unfortunately, this method absolutely requires: (i) knowledge of the target antigen; (ii) availability of T cell clones; and (iii) a relatively short overall length for the target source protein, such that a set of overlapping pep tides can be affordably synthesi
出版日期Book 1996
關鍵詞T cell; antigen; antigen presentation; autoimmune disease; cognition; cytotoxicity; diseases; evolution; his
版次1
doihttps://doi.org/10.1007/978-1-4684-6462-7
isbn_ebook978-1-4684-6462-7
copyrightR.G. Landes Company and Chapman & Hall 1996
The information of publication is updating

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Polypeptide Release from Lysosomes,eneous in appearance (Fig. 5.1), and identification of electron dense cytoplasmic structures as lysosomes depended initially on microscopic cytochemical indications of the presence of specific hydrolases.. Currently, lysosomes are identified immunocytochemically, using antibodies to specific hydrolases or membrane marker, such as LGP 120..
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The Role of HLA-DM in Class II Antigen Presentation,y and MHC class I and class II molecules bind peptides derived from different cellular locations: peptides derived from mainly cytoplasmic sources bind to class I whereas proteins taken up from the extracellular environment are degraded and bind to class II.
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