書目名稱 | MHC Class I Antigens In Malignant Cells |
副標題 | Immune Escape And Re |
編輯 | Natalia Aptsiauri,Angel Miguel Garcia-Lora,Teresa |
視頻video | http://file.papertrans.cn/621/620150/620150.mp4 |
概述 | Discusses molecular mechanisms of total or partial loss of the MHC class I antigens in cancer cells.Explains the role of MHC class I defects in cancer progression.Shows the correlation of MHC class I |
叢書名稱 | SpringerBriefs in Cancer Research |
圖書封面 |  |
描述 | Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence?that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches.?A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy. ?Precise identification of the mechanism leading to MHC class I defects ?will help to develop new personalized patient-tailored treatment protocols.?There is significant new research?on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer. In contrast, few data is?available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that?show?the?progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunothe |
出版日期 | Book 2013 |
關(guān)鍵詞 | Immunotherapy; MHC class I; cancer; immune escape; metastasis; tumor rejection |
版次 | 1 |
doi | https://doi.org/10.1007/978-1-4614-6543-0 |
isbn_softcover | 978-1-4614-6542-3 |
isbn_ebook | 978-1-4614-6543-0Series ISSN 2194-1173 Series E-ISSN 2194-1181 |
issn_series | 2194-1173 |
copyright | Maria Teresa Cabrera Castillo 2013 |