Titlebook: Lung Cancer Metastasis; Novel Biological Mec Venkateshwar Keshamouni,Douglas Arenberg,Gregory K Book 2010 Springer-Verlag New York 2010 ang

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Molecular Control of Lymphatic Metastasis in Lung Cancer, and central component of the lung carcinoma TNM staging system. In recent years, genetic studies in mouse models as well as pathologic human lung cancer studies have revealed a variety of molecules that may critically regulate thoracic lymph node metastasis. These include important lymphatic endoth

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Carcinoma-Associated Fibroblasts in Lung Cancer,s. Therefore, the stromal cells surrounding cancer epithelial cells, rather than being passive bystanders, appear to have an important role in modifying tumor development and progression. Clinical evidence also supports the significant contribution of stroma to the development of a wide variety of t

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The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression ofspread. Given that macrophages are the most frequent hematopoietic cells found in the tumor microenvironment, they play an especially important part in tumor biology. There are numerous mechanisms by which tumor-associated innate immune cells can influence most aspects of the metastatic process. The

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Molecular Imaging in Lung Cancer Metastases, cancer and the spread of malignancy to distant organs. Molecular imaging is a very promising technology which provides the potential for utilizing these biomarkers for monitoring tumor progression and therapeutic response. This technology may allow real-time, dynamic, and quantifiable monitoring of

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Biomarker Discovery for Metastatic Disease,markers and targets for therapy. A systems biology approach that encompasses differential expression of mRNAs (gene expression), microRNAs (gene regulators), and proteins in primary and metastatic tumors, in proximal biofluids, and in the blood plasma generates potentially complementary molecular si

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Site-Directed Therapy for Lung Cancer Metastases,dvanced metastatic disease. The prognosis of patients with advanced lung cancer is dismal, with a 5-year overall survival rate of 1–2%. The primary treatment of advanced disease is supportive care and palliative chemotherapy. However, there is a growing body of evidence suggesting that highly select

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Venkateshwar Keshamouni,Douglas Arenberg,Gregory KWill provide important insights into current research in this area.The area of lung cancer metastasis is a very timely subject in view that lung cancer remains the number 1 cause of cancer death in bo