Titlebook: Long Noncoding RNA; Mechanistic Insights Susan Carpenter Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license

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The Complexity of the Mammalian Transcriptomeeloped in the early 2000s revealed that the mammalian transcriptome was vastly larger and more complex than previously anticipated. Efforts to comprehensively catalog the identity and features of transcripts present in a variety of species, tissues and cell lines revealed that a large fraction of th

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Long Non-coding RNAs in Rheumatologytein encoding RNA transcripts that exceed 200 nucleotides in length. These transcripts have tissue and cell specific patterns of expression and are implicated in a variety of biological processes. Unsurprisingly, numerous lncRNAs are dysregulated in rheumatoid conditions, correlating with disease ac

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A Role for lncRNAs in Regulating Inflammatory and Autoimmune Responses Underlying Type 1 Diabetesic islets. Genetic and transcriptome studies for T1D indicate that a relatively large number of long noncoding RNAs (lncRNAs), detected in both immune cells and β cells, contribute to the underlying inflammation and autoimmune pathology. Although lncRNAs do not encode proteins, their biochemical ver

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