Titlebook: Long Non-coding RNAs in Human Disease; Kevin V. Morris Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive license

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Long Non-coding RNA , and , in Human Cancers and Cardiovascular Disease, 9 on p21.3 that overlaps a critical region encompassing three major tumor suppressor loci juxtaposed to the .-.-. gene cluster and the methyl-thioadenosine phosphorylase (.) gene. Genome-wide association studies have identified this region with a remarkable and growing number of disease-associated

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Form and Function of Exosome-Associated Long Non-coding RNAs in Cancer,f investigation. LncRNAs have been found to be functional in the regulation of a wide variety of genes, including those involved in cancer. Studies have identified that lncRNAs play a role in the development and regulation of cancer and can also act as prognostic markers. Meanwhile, exosomes, which

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Long Noncoding RNAs in Lung Cancer,utations in protein-encoding genes were defined and allow for personalized therapies based on genetic diagnoses. Nonetheless, diagnosis of lung cancer mostly occurs at late stages, and chronic treatment is followed by a fast onset of chemoresistance. Hence, there is an urgent need for reliable bioma

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condone

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Long Noncoding RNAs as Targets and Regulators of Nuclear Receptors,e remained elusive for the most part. Nuclear receptors that interpret signaling mediated by small molecule hormones play a role in regulating the expression of some long noncoding RNAs. More importantly, these RNAs have also been shown to effect hormone-affected gene transcription regulated by the

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Noncoding Transcriptional Landscape in Human Aging,lity and morbidity. Aging of an organism correlates with a decline in function of its cells, as shown for muscle, immune, and neuronal cells. As the DNA content of most cells within an organism remains largely identical throughout the life span, age-associated transcriptional changes must be achieve

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lncRNAs in Stress Response, lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in cellular response to stressful conditions. lncRNAs constitute a significant fraction of the genes di

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Expression Specificity of Disease-Associated lncRNAs: Toward Personalized Medicine,isregulation of lncRNAs is found linked to various human diseases. Compared to protein-coding RNAs? lncRNAs are more specific to organs, tissues, cell types, developmental stages, and disease conditions? making them promising candidates as diagnostic and prognostic biomarkers and as gene therapy tar

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sen sich auf unterschiedliche Weisen interpretieren. Welche ist jedoch die richtige? Die g?ngigen Methoden l?sen diese Frage durch den Rückgriff auf mehr oder weniger explizite theoretische Vorannahmen und Brückenhypothesen. üblicherweise wird das Soziale als etwas konzeptualisiert, das ?hinter“ ode