Titlebook: Liver Growth and Repair; Alastair Strain,Anne Mae Diehl Book 1998 Springer Science+Business Media Dordrecht 1998 cells.cyclin.development.

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Transgenic animals as models for hepatocarcinogenesis and more recently gene knockout techniques. Both these approaches have been extremely valuable and important in defining . the role and impact of genes thought to either favor or suppress normal and neoplastic cell growth. With these methodologies, we can generate animal models to dissect out genet

Monolithic

Ergots

The EGF/TGFα family of growth factors and their receptorsactivity from mouse submaxillary glands, Cohen (1962) observed that injections of certain purified fractions accelerated eyelid opening and incisor tooth eruption when injected into newborn mice. In a series of now classic studies, he and his colleagues then isolated and characterized mouse EGF, a 5

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ACRID

The fibroblast growth factor familyge such as partial hepatectomy or chemical treatment. In the process, most of the hepatocytes as well as non-parenchymal liver cells divide, accompanied by alterations in patterns of gene expression. Cultured hepatocytes, isolated from liver by collagenase perfusion, undergo DNA synthesis and prolif

CREST

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Proto-oncogenes/ transcription factors of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress-related or required for the continued differentiated function of the liver while regeneration is occurring.

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Cyclins and gap junctions in liver growth and repairduring the synchronized cell cycles induced by liver regeneration following partial hepatectomy. This chapter begins with an introduction to the cyclin gene family, and continues with a discussion of the various cyclin functions in cellular control, with emphasis on eukaryotic cells and in particula

Veneer

Intracellular signal transduction in liver regeneration urea synthesis, which help to maintain homeostasis of carbohydrates, amino acids and fats. The liver is also critical in lipoprotein metabolism, is responsible for albumin synthesis and bile production, and is the primary site for detoxification of drugs and other xenobiotics in the body. Most of t

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