Titlebook: Lipoxygenases in Inflammation; Dieter Steinhilber Book 2016 Springer International Publishing Switzerland 2016 allergic and cardiovascular

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5-Lipoxygenase,c acid. The expression of 5-LO is essentially limited to myeloid cells but 5-LO can be expressed also in non-myeloid cancer cells. In contrast to other human LOs, 5-LO enzyme activity is tightly regulated by interacting proteins and several co-factors including Ca./Mg., ATP, phospholipids, diglyceri

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Leukotriene A4 Hydrolase and Leukotriene C4 Synthase,ism. Leukotriene B. is one of the most potent chemotactic agents known while leukotriene C., D., and E. are a powerful smooth muscle contracting agents, particularly in the respiratory tract and microcirculation. The committed steps in the biosynthesis of leukotriene B. and C. are catalyzed by the k

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Gerontology

Platelets and Lipoxygenases,le in hemostasis, platelets are also known to regulate inflammation. These small anucleated cells express a single lipoxygenase, platelet 12(S)-LOX, which is capable of oxidizing a number of fatty acids. Depending on the fatty acid, the metabolite(s) produced by 12(S)-LOX have often been shown to im

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Lipoxygenases and Cardiovascular Diseases,ted to several cardiovascular diseases, such as atherosclerosis. The polyunsaturated omega-6 fatty acid arachidonic acid serves as a substrate for 5-LO, 12- and 15-LO, which catalyzes the formation of several bioactive lipid mediators. For example, 5-LO-derived leukotrienes transduce pro-inflammator

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Role of Lipoxygenases in Pathogenesis of Cancer,ostate and breast cancer. Recently, a role of 5-lipoxygenase was reported in hemato-oncological tumors, such as chronic myeloid leukemia and acute myeloid leukemia. Whereas 5-lipoxygenase and 12-lipoxygenase are generally recognized as pro-carcinogenic, the related enzyme 15-lipoxygenase-2 is down-r

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5-Oxo-ETE and Inflammation,highly selective dehydrogenase 5-HEDH, which is expressed in both inflammatory and structural cells. Its synthesis is regulated by the availability of the obligate cofactor NADP. and is favored by conditions such as oxidative stress and activation of the respiratory burst in phagocytic cells. The ac