Titlebook: Lipoxygenases and their Metabolites; Biological Functions Santosh Nigam,Cecil R. Pace-Asciak Book 1999 The Editor(s) (if applicable) and Th

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Commonwealth

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dura-mater

連鎖,連串

Molecular Cloning of a Second Human 15,-Lipoxygenase and its Murine Homologue, an 8,-Lipoxygenase,ppear to have distinct biological roles. The leukocyte 5S-lipoxygenase clearly functions in the initiation of a metabolic pathway; the leukotriene products have distinct cell receptors and mediate proin-flammatory activities. The platelet 12S lipoxygenase synthesizes 12.-HpETE, and following reducti

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Expression of Leukocyte-Type 12-Lipoxygenase and Reticulocyte-Type 15-Lipoxygenase in Rabbits,he rabbit 15-lipoxy-genase. HPLC product analysis of the bacterially expressed protein identified it as a leukocyte-type 12-lipoxygenase (1.12-LOX). This proves the co-expression of a 15-lipoxygenase and a 1.12-lipoxygenase in one mammalian species. Among the six amino acids that are different to ra

CHART

Lipoxygenase Gene Disruption Studies,istinct from other lipoxygenase genes in its large size and its location on a separate chromosome (10q1 1.2 in humans and central chromosome 6 in mice) (1-5). A cluster of lipoxygenase genes located on mouse chromosome 11 (5,6) contains genes that encode three distinct 12(S)-lipoxy-genases, referred

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The Release of Polyunsaturated Fatty Acids and Their Lipoxygenation in the Brain,ydrolyze 20:4n6 and 22:6n3 equally well under both stimulated and basal conditions. Despite the high abundance of 22:6n3 in neuronal membranes, 20:4n6 is preferentially hydrolyzed from neuronal cells. These results suggest that 22:6n3 may be of more physiological importance in neuronal membranes as