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Titlebook: Lipids in Protein Misfolding; Olga Gursky Book 2015 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer N

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發(fā)表于 2025-3-21 19:47:52 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Lipids in Protein Misfolding
編輯Olga Gursky
視頻videohttp://file.papertrans.cn/587/586895/586895.mp4
概述Explains how protein misfolding is an important biological phenomenon underlying over 20 major human diseases.Shows that Lipids importantly influence protein misfolding and amyloid diseases.Provides a
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Lipids in Protein Misfolding;  Olga Gursky Book 2015 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer N
描述?Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence? protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.
出版日期Book 2015
關(guān)鍵詞amyloid formation; biophysical and structural approaches; molecular mechanisms of protein misfolding; p
版次1
doihttps://doi.org/10.1007/978-3-319-17344-3
isbn_softcover978-3-319-37205-1
isbn_ebook978-3-319-17344-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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發(fā)表于 2025-3-21 23:07:12 | 只看該作者
0065-2598 influence protein misfolding and amyloid diseases.Provides a?Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific c
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Olga GurskyExplains how protein misfolding is an important biological phenomenon underlying over 20 major human diseases.Shows that Lipids importantly influence protein misfolding and amyloid diseases.Provides a
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https://doi.org/10.1007/978-3-319-17344-3amyloid formation; biophysical and structural approaches; molecular mechanisms of protein misfolding; p
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Lipids in Protein Misfolding978-3-319-17344-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
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Protein Misfolding in Lipid-Mimetic Environments,elations between the aggregating proteins and cell membranes. On one hand, the unstable, toxic pre-fibrillar aggregates may interact with cell membranes, impairing their functions, altering ion distribution across the membranes, and possibly forming non-specific membrane pores. On the other hand, me
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