Titlebook: Levodopa-Induced Dyskinesia in Parkinson‘s Disease; Susan H. Fox,Jonathan M. Brotchie Book 2014 Springer-Verlag London 2014 Parkinson‘s di

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Pharmacological Treatment Options for Levodopa-Induced Dyskinesia,lude the antiglutamatergic drug amantadine and the antipsychotic clozapine (which carries a risk of leukopenia and requires regular blood checks)..In patients with motor complications refractory to all adjustments of oral and transdermal treatments and where deep brain stimulation is either contrain

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Pharmacological Properties of Levodopa, which is thought to be a key determinant underlying the dyskinetic state. Therapeutic approaches that would produce continuous drug delivery (CDD) and ensuing continuous dopaminergic stimulation (CDS) have been actively sought. After a brief historical review, this chapter summarizes the biochemica

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Involvement of the Cholinergic System in Levodopa-Induced Dyskinesia, acting at nAChRs, with the α4β2, α6β2, and α7 receptor subtypes all contributing to the occurrence of LID. An involvement of multiple subtypes in LID is also supported by studies with drugs targeting select nAChR populations. Notably, nicotine and nAChR drugs did not worsen parkinsonism in any anim

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New Clinical Trials for Levodopa-Induced Dyskinesia,odopa-sparing agents on LID is also being investigated, both in early and advanced PD. Moreover, non-dopaminergic agents are being studied as add-on therapies in established LID. Such agents are also being studied in early PD, either as monotherapy to improve parkinsonian symptoms without causing dy

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ced Dyskinesia in Parkinson’s Disease. is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students..978-1-4471-7238-3978-1-4471-6503-3

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Elisabetta Tronci,Camino Fidalgo,Manolo Cartan anschlie?end wird der Versuch unternommen, Interessen in ihrem multidimensionalen und prozesshaften Charakter als ?Interessierung“ neu zu fassen und in ihren Implikationen für Th978-3-658-33726-1978-3-658-33727-8

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