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Titlebook: Leptin; V. Daniel Castracane (Professor Emeritus and Direc Book 2007 Springer-Verlag US 2007 bone.hormone.leptin receptors.metabolism.neur

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發(fā)表于 2025-3-21 16:56:24 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Leptin
編輯V. Daniel Castracane (Professor Emeritus and Direc
視頻videohttp://file.papertrans.cn/586/585001/585001.mp4
概述The timing of this volume is long overdue and it will be the first comprehensive coverage of leptin physiology in the field.Includes supplementary material:
叢書名稱Endocrine Updates
圖書封面Titlebook: Leptin;  V. Daniel Castracane (Professor Emeritus and Direc Book 2007 Springer-Verlag US 2007 bone.hormone.leptin receptors.metabolism.neur
描述The discovery of leptin by Friedman and his colleagues in 1994 was a seminal discovery in the study of metabolism, providing a new tool to study energy expenditure and appetite regulation. Early studies actively investigated many aspects of metabolism, obesity, and diabetes but it was soon evident that leptin was much more than a metabolic hormone. Today leptin, with almost 11,000 reports in the world‘s literature, is recognized to be important in many areas of physiology with strong suggestions for involvement in clinical conditions as well. Leptin, of course, remains of great interest in obesity and diabetes but other, previously unimagined, areas are now in the realm of leptin physiology. Perhaps leptin and its involvement in many areas of reproductive physiology may be of greatest interest outside of obesity, but other physiological arenas are becoming increasingly involved in the broader understanding of leptin and its pleiotropic functions. These areas include cardiovascular disease, bone physiology, immune regulation, and even cancer and genetics. Clinical trials have suggested other areas of leptin pharmaceutical potential beyond the original promise of obesity management.
出版日期Book 2007
關鍵詞bone; hormone; leptin receptors; metabolism; neuroendocrinology; obesity; physiology; protein; reproduction
版次1
doihttps://doi.org/10.1007/978-0-387-31416-7
isbn_softcover978-1-4419-4065-0
isbn_ebook978-0-387-31416-7Series ISSN 1566-0729
issn_series 1566-0729
copyrightSpringer-Verlag US 2007
The information of publication is updating

書目名稱Leptin影響因子(影響力)




書目名稱Leptin影響因子(影響力)學科排名




書目名稱Leptin網(wǎng)絡公開度




書目名稱Leptin網(wǎng)絡公開度學科排名




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書目名稱Leptin被引頻次學科排名




書目名稱Leptin年度引用




書目名稱Leptin年度引用學科排名




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書目名稱Leptin讀者反饋學科排名




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沙發(fā)
發(fā)表于 2025-3-21 22:47:31 | 只看該作者
Leptin Receptors,o be linked with intracellular signaling, and only the longest isoform (ObRb) has full signaling capability. Structure/function analyses of the receptor of the dimer pair reversibly binds a single leptin molecule. Upon binding, signaling cascades are initiated beginning with activation of receptor-a
板凳
發(fā)表于 2025-3-22 01:53:37 | 只看該作者
Leptin and Obesity, tissue depots contribute to greater serum leptin in women than men of equivalent fat mass. Serum leptin circulates in the plasma in association with a binding protein comprised of the extracellular domain of the leptin receptor. The postprandial surge in insulin and glucose stimulate leptin synthes
地板
發(fā)表于 2025-3-22 08:15:43 | 只看該作者
Leptin and Neuroendocrinology,s one of the most important peripheral signals involved in the variety of neuroendocrine functions, including the regulation of food intake and body weight. Because the hypothalamus is a major site for integration of central and peripheral signals for the maintenance of energy homeostasis and many o
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發(fā)表于 2025-3-22 12:41:56 | 只看該作者
Leptin-Insulin Interrelationships,vels correlate with adipose tissue mass. Via hypothalamic leptin receptors (ObR), it restricts food intake and increases energy expenditure in normal individuals. Leptin is implicated in decreased production and secretion of insulin by the pancreatic beta (β) cell. Insulin, conversely, stimulates le
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發(fā)表于 2025-3-22 15:07:53 | 只看該作者
Leptin and Other Endocrine Systems,arvation is a signal to reduce energy expenditure by limiting thyroid hormone, growth hormone, and gonadal hormone secretion and y increasing cortisol release. The leptin signal is primarily mediated through receptors located within hypothalamic nuclei, although some effects may occur by leptin bind
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發(fā)表于 2025-3-22 17:03:14 | 只看該作者
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發(fā)表于 2025-3-22 23:33:32 | 只看該作者
Leptin and Bone Central control of bone metabolism by leptin,rvous system, leptin inhibits bone formation via CREB, AP-1 and the molecular clock, while stimulates bone resorption via ATF4. Moreover, leptin also inhibits bone resorption via CART through an unidentified mechanism.
9#
發(fā)表于 2025-3-23 02:58:39 | 只看該作者
Roles and Regulation of Leptin in Reproduction,tility, and pregnancy. Therefore, second only to its association with obesity, leptin’s role as a reproductive regulator represents the primary research focus of the scientific community to date. A correlation with adipose mass is at least partly responsible for serum leptin concentrations being hig
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發(fā)表于 2025-3-23 08:11:35 | 只看該作者
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