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Titlebook: Leptin; Regulation and Clini Sam Dagogo-Jack, MD Book 2015 Springer International Publishing Switzerland 2015 Dysleptinemia.ELISA.Glucocort

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發(fā)表于 2025-3-21 18:36:00 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Leptin
副標(biāo)題Regulation and Clini
編輯Sam Dagogo-Jack, MD
視頻videohttp://file.papertrans.cn/585/585000/585000.mp4
概述Emphasizes metabolic pathophysiology and clinical applications of leptin in humans.Presents therapeutic trials of recombinant leptin replacement in humans for a variety of disorders.Considers the futu
圖書封面Titlebook: Leptin; Regulation and Clini Sam Dagogo-Jack, MD Book 2015 Springer International Publishing Switzerland 2015 Dysleptinemia.ELISA.Glucocort
描述.Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone..Leptin .provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in t
出版日期Book 2015
關(guān)鍵詞Dysleptinemia; ELISA; Glucocorticoids; Homeostasis; Hormonal regulation; Hypertension; Hypothalamus; Leptin
版次1
doihttps://doi.org/10.1007/978-3-319-09915-6
isbn_softcover978-3-319-35413-2
isbn_ebook978-3-319-09915-6
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

書目名稱Leptin影響因子(影響力)




書目名稱Leptin影響因子(影響力)學(xué)科排名




書目名稱Leptin網(wǎng)絡(luò)公開度




書目名稱Leptin網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱Leptin被引頻次




書目名稱Leptin被引頻次學(xué)科排名




書目名稱Leptin年度引用




書目名稱Leptin年度引用學(xué)科排名




書目名稱Leptin讀者反饋




書目名稱Leptin讀者反饋學(xué)科排名




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發(fā)表于 2025-3-21 21:41:03 | 只看該作者
Leptin Interaction with Brain Orexigenic and Anorexigenic Pathways,receptor gene or genes that impair the function of downstream leptin circuits in the brain, attenuated leptin receptor signal transduction, and brain inflammatory mechanisms. fMRI imaging studies suggest that similar mechanisms of leptin action operate in the human brain as has been established in r
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發(fā)表于 2025-3-22 02:17:21 | 只看該作者
Physiological and Hormonal Factors that Influence Leptin Production,s, including insulin, glucocorticoids, growth hormone, estradiol, testosterone, insulin-like growth factor-I, and somatostatin also modulate leptin secretion. In addition to alteration of circulating leptin levels, evidence of an effect on leptin synthesis (as indicated by adipose tissue leptin mRNA
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Leptin in Acute Stress,g both increased insulin levels and an acute need for energy, blunts the insulin-induced rise in leptin or reduces leptin. While leptin is inconsistently affected by bouts of shorter duration exercise, prolonged endurance exercise acutely decreases leptin levels. During pregnancy, maternal leptin le
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Dynamic Leptin Secretion in Obesity and Diabetes,betes. Healthy subjects respond with a doubling of plasma leptin levels following challenge with a single dose (1–4 mg) of dexamethasone, and also show ~50 % increase in leptin levels following infusion of insulin under clamped euglycemic conditions. Evaluation of dynamic leptin secretion across a w
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Leptin Therapy in People with a Normal Leptin Gene,h the pivotal metreleptin and PEG-OB randomized double-blind placebo-controlled studies showed modest but statistically significant weight loss in overweight and obese subjects at relatively high subcutaneously administered doses. A wide range of secondary outcomes were evaluated, although most repo
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