Titlebook: Lentiviral Vectors; Didier Trono Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag Gmb

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Biosafety Issues in Lentivector Production,to be used in the clinic, these vectors will have to comply with a complete set of requirements regarding their mode of preparation and characterization. Over the past 50 years, there has been an increasing awareness of the safety issues surrounding the manufacturing of medicinal products. Regulator

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Lentiviral Vector Targeting, . et al. (2000) and . et al. (2000) have brought to gene therapists and their patients a new wave of optimism. Even so, there is conspicuous criticism of the high cost and complexity of gene therapy procedures. In large part, this relates to the shortcomings of the mode of gene delivery to the affe

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Improving the Post-Transcriptional Aspects of Lentiviral Vectors, vectors represent a new transgene delivery system, which holds great promise because of its ability to stably transduce nondividing cells. To develop the next generation of these vectors it is essential to increase biosafety and optimize the efficiency of transgene expression. Elements derived from

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Lentiviruses as Vectors for CNS Diseases, mouse models (. et al. 1996), the use of gene-chip technology (. 1999) and the development of functional imaging (. et al. 1999) have drastically modified our understanding of the molecular events leading to the cellular dysfunction and ultimately the degeneration of specific populations of neurons

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Lentiviral Vectors for the Gene Therapy of Lympho-Hematological Disorders,station of a large number of well-characterized monogenic hereditary defects, the correction of which would eliminate all symptoms in affected individuals (Table 1). Second, adding a genetic component to currently used drug-based approaches could facilitate the control of several acquired diseases o

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Lentiviral Vectors for Gene Therapy of HIV-Induced Disease,to combat HIV infection. Combination antiretroviral drugs can effectively reduce HIV RNA in peripheral blood and lymphoid tissue to undetectable levels (. et al. 1996; . et al. 1997). The advent of highly active antiretroviral therapy (HAART) initially raised expectations for the possibility of comp

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Book 2002For the first time a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.

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https://doi.org/10.1007/978-3-642-56114-6CNS; HIV; Lentiviral vectors; biology; development; diseases; gene; gene therapy; gene transfer; genes; immuno

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0070-217X lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.978-3-642-62667-8978-3-642-56114-6Series ISSN 0070-217X Series E-ISSN 2196-9965