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Titlebook: Lead-Seeking Approaches; Matthew M. Hayward,J. A. Bikker,M. Pellecchia Book 2010 Springer-Verlag Berlin Heidelberg 2010 chemistry.medicina

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21#
發(fā)表于 2025-3-25 03:19:44 | 只看該作者
22#
發(fā)表于 2025-3-25 07:56:16 | 只看該作者
23#
發(fā)表于 2025-3-25 14:09:04 | 只看該作者
Hit Triage: Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery,age in drug discovery. It explains, in general, the sources of hits for a drug discovery program and explores the link between potency and efficiency in evaluating lead matter. The chapter then illustrates the collection of both pharmacokinetic data as well as safety data, and describes the relevanc
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發(fā)表于 2025-3-25 16:29:51 | 只看該作者
25#
發(fā)表于 2025-3-25 23:31:50 | 只看該作者
NMR Spectroscopy in Fragment Based Drug Design,ecular interactions. By way of examples, we will illustrate the unique advantages that these techniques offer when employed in conjunction with fragment-based ligand design, especially when tackling challenging drug targets.
26#
發(fā)表于 2025-3-26 00:12:17 | 只看該作者
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發(fā)表于 2025-3-26 06:46:47 | 只看該作者
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發(fā)表于 2025-3-26 08:57:27 | 只看該作者
Book 2010 an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of co
29#
發(fā)表于 2025-3-26 14:09:28 | 只看該作者
30#
發(fā)表于 2025-3-26 20:11:58 | 只看該作者
Hit Triage: Medicinal Chemistry Strategies to Improve the Odds of Success in Discovery,e of that data and the process of using it to make decisions. Of course, there is no one “right” or “wrong” way to do the work contained in this chapter, but the practice of efficiently building a network of information on compounds, and then using that to make informed decisions can help to shift the odds of success in drug discovery.
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