Titlebook: Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3; Basic Science and Cl David A. Sullivan,Michael E. Stern,B. Britt Brombe Book 2002 The E

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GDNF Family Signalling in Exocrine Tissues: Distinct Roles for GDNF and Neurturin in Parasympatheticoup in the transforming growth factor-β superfamily. They signal by binding to a receptor complex consisting of a ligand-binding GPI-anchored GDNF family receptor a (GFRα1 to GFRα4) and the trans-membrane tyrosine kinase Ret (for review see references 1–3). A schematic view of the GDNF family signaling is shown in Fig. 1.

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Lipase mRNAs Expressed in Lacrimal and Harderian Glandss aqueous evaporation and protects the ocular surface from environmental irritants. The lacrimal glands supply the bulk of the ocular tear fluid phase, as well as many dissolved proteins. The meibomian glands of the eyelid secrete the lipids. Harderian glands of non-primate vertebrates secrete proteins and lipids.

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978-1-4613-5208-2The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines

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ssant. Although these drugs have much toxicity, there is insufficient data to show that CNI-free immunosuppression is safe or feasible from the time of transplantation. Most centers also use an additional adjunctive agent, either in the form of an antimetabolite (azathioprine [AZA] or mycophenolate