Titlebook: LHRH and Its Analogs; Contraceptive and Th B. H. Vickery,J. J. Nestor Book 1987 MTP Press Limited 1987 contraception.fertility.hormones.pla

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Molecular Mechanism of LHRH Action in the Gonadotropeetriosis, steroid-dependent neoplasia and precocious puberty. Such clinical advances have occurred largely as a result of improved understanding of the molecular and cellular mechanism of action of LHRH at the gonadotrope.

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Histamine Release with LHRH Analogse development of LHRH antagonists as potential contraceptive agents. This observation suggested that LHRH analogs might release histamine and other inflammatory mediators from cells. Subsequently, accounts of .. histamine release by LHRH analogs were reported by Nekola ...

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Anaphylactoid Properties of LHRH Analogspositions 2, 3 and 6 have been among the most effective, although the structure activity relationships in this work appear to be very complex. One series of analogs with an arginine substituted at position 6 appears to be most potent [5,6]. One of these, [N-Ac-D-Nal(2)., D-pF-Phe., D-Trp., D-Arg.] LHRH has been proposed for clinical studies.

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978-94-010-7949-5MTP Press Limited 1987

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