Titlebook: Kinetic Data Analysis; Design and Analysis Laszlo Endrenyi Book 1981 Plenum Press, New York 1981 biochemistry.chemistry.data analysis.desi

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Experimental Designs for the Distribution-Free Analysis of Enzyme Kinetic Datanse that the overall variance of the parameter estimates is minimized. Formulae are given for choosing the optimal designs for selected cases and a worked example of the design and analysis of a competitive inhibition experiment is presented.

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A Priori Identifiability Analysis in Pharmacokinetic Experiment Design detail, namely the nonlinear saturable models, the linear or linearizable models and the linear compartmental models. Available methods for testing in practice identifiability for these three classes of experiment design models are reviewed, compared and exemplified. Connections between the identif

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A Frequency Response Method for Pharmacokinetic Model Identificationdescriptions of both the nonlinear least-squares estimation technique in the time domain and the frequency domain estimation technique are presented here. The frequency response data obtained by pulse testing are fitted with accurate model parameters by using a nonlinear least-squares estimation tec

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Design and Analysis of Kinetic Experiments for Discrimination between Rival Modelsnd statistical analysis of the results. The criteria involve consideration of convergence properties of a model, examination of parameter values, analysis of residuals, and comparison of residual sums of squares of rival models with one another as well as with the experimental variance. The design o

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Book 1981itional material. The present volume is the result. It is an attempt to convey some of the interdisciplinary concerns involv- ing mechanistic, and especially kinetic, model building. The coverage is by no means exhaustive: many principles, methods, and problems are not included. Even the application

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Donald G. Wattsl information guarantees successful observing sessions. The book could become a standard source on galaxy observing for all kinds of amateur observers, from the beginner to the experienced..978-1-85233-752-0978-1-84628-699-5Series ISSN 1611-7360 Series E-ISSN 2197-6546