| 書目名稱 | Killer Lymphocytes | | 編輯 | Gideon Berke,William R. Clark | | 視頻video | http://file.papertrans.cn/543/542718/542718.mp4 | | 概述 | Advanced analysis of the field of cell-mediated cytotoxicity, including a comprehensive examination of key papers underlying its evolution.Thorough discussion of the most recent advances in the field. | | 圖書封面 |  | | 描述 | The existence of a unique kind of immune cell – the killer lymphocyt- which destroys other cells in a highly specific manner, has fascinated immunologists for almost half a century. How do these cells, whose precursors have lived in communal harmony with their host, decide that some of their cohabitants must die? And how do they kill them? The definition of killer lymphocytes came from discovery of their roles in a wide range of in vivo phenomena such as transplant rejection, virus infection and its related immunopathologies, and anti-tumor responses. Yet for the most part almost everything we know about these cells has come from studying them in vitro. They have yielded their secrets slowly and reluctantly. To understand fully how they work, geneticists and immunologists had to unravel the major histocompatibility systems of vertebrates, a long and torturous road that provided some of the darkest hours of immunology. The search for antigen-sensing receptors on both T cells and NK cells was scarcely less frustrating. And the holy grail of ce- mediated cytotoxicity – defining the mechanism by which killer cells take down their adversaries – sorely tested the ingenuity, patience and | | 出版日期 | Book 2007 | | 關鍵詞 | Berke, Clark, Lymphocytes, CTL; NK cells; cytotoxicity; immunobiology; viro | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4020-3270-7 | | isbn_softcover | 978-1-4020-6563-7 | | isbn_ebook | 978-1-4020-3270-7 | | copyright | Springer Science+Business Media B.V. 2007 |
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