Titlebook: Keratoprostheses and Artificial Corneas; Fundamentals and Sur M. Soledad Cortina,Jose de la Cruz Book 2015 Springer-Verlag Berlin Heidelber

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The History of Keratoplasty: A Brief Overview. For the contemporary corneal surgeon interested in keratoprosthesis surgery, understanding the historical landmarks of both keratoplasty and prosthokeratoplasty is important to the recognition of the obstacles we face to finding a successful artificial cornea.

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The Anatomy and Physiology of Corneaet’s membrane. Corneal stroma is composed of cellular (keratocytes) and extracellular components. Cornea is an immune-privileged tissue due to the absence of blood and lymphatic vessels. Although normal cornea is an avascular, many conditions can cause neovascularization, scarring, and corneal blindness.

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History of the Artificial Corneaoperation one could attempt… Use a clear, thin piece of glass…convex outside, with the diameter of the cornea, place it inside a small circle of silver… Around the exterior circle, have a groove made proportional to the thickness of the natural cornea so that the sclera can exactly adapt to it by secreting new juices….”

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