Titlebook: Jak-Stat Signaling : From Basics to Disease; Thomas Decker,Mathias Müller Book 2012 Springer-Verlag Wien 2012 Cell Differentiation.Hematop

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Activation of Janus Kinases During Tumorigenesis,or mammalian development, and conventional knockout models in mice show that the absence of just one of these two kinases causes prenatal and postnatal lethality. Recent studies using JAK2 conditional knockout mice show that this tyrosine kinase plays key roles in mammary gland development, fertilit

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ellagic-acid

Universal and Specific Functions of STAT3 in Solid Tumours,ressive disease and bad prognosis. Persistent STAT3 activity, to which tumours often become addicted, is mostly due to the aberrant activation of pro-oncogenic/pro-inflammatory signals that can trigger its phosphorylation, such as oncogenes, growth factor receptors and cytokines. Among STAT3-mediate

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Crosstalk with the Jak-STAT Pathway in Inflammation,omes of Jak-STAT signaling are modulated by signaling crosstalk with heterologous signaling pathways. Conversely, Jak-STAT signaling regulates cell responses to multiple cytokines and inflammatory factors. Emerging evidence suggests that on balance Jak-STAT signaling is pathogenic in chronic inflamm

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arterioles

Thomas Decker,Mathias Müller research is focused primarily on the conveyor idlers load determination by numerical simulation of the contact between the conveyor belt and idlers. A nonlinear theory of the finite element method is applied, taking into account the effects of large displacements and the contact problems. The basic

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exorbitant

Mark A. Dawson,Andrew J. Bannister research is focused primarily on the conveyor idlers load determination by numerical simulation of the contact between the conveyor belt and idlers. A nonlinear theory of the finite element method is applied, taking into account the effects of large displacements and the contact problems. The basic

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Amanda M. Jamieson,Matthias Farlik,Thomas Decker under fire conditions.Provides the theoretical and practica.This book presents the comprehensive results of experimental and numerical investigations of glass fa?ade breakage behavior under fire conditions. First of all, full-scale frame and point-supported glass fa?ades, incorporating single, doub