| 書目名稱 | Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants | | 副標(biāo)題 | New Vistas In Parkin | | 編輯 | Lucyna Antkiewicz-Michaluk,Hans Rommelspacher | | 視頻video | http://file.papertrans.cn/476/475774/475774.mp4 | | 概述 | Contains up-to-date research.Written by field experts.In-depth look at a complex topic.Includes supplementary material: | | 叢書名稱 | Current Topics in Neurotoxicity | | 圖書封面 |  | | 描述 | .?????? The specific topic, “Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson`S Disease Therapy,” was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson`s disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): .?.-carbolines (BCs) and tetrahydroisoquinolines? (TIQs). These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has | | 出版日期 | Book 2012 | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-1542-8 | | isbn_softcover | 978-1-4899-8754-9 | | isbn_ebook | 978-1-4614-1542-8Series ISSN 2363-9563 Series E-ISSN 2363-9571 | | issn_series | 2363-9563 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
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