Titlebook: Isoprenoid Synthesis in Plants and Microorganisms; New Concepts and Exp Thomas J. Bach,Michel Rohmer Book 2013 Springer Science+Business Me

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Control of Plastidial Isoprenoid Precursor Supply: Divergent ,,, (,) Isogenes Regulate the Allocatihe discovery of two divergent gene classes encoding the first enzyme of the plastidial methylerythritol phosphate (MEP) pathway. These nonredundant ... (.) isogenes are differentially expressed in such a way that DXS1 appears to serve housekeeping functions, whereas DXS2 is associated with the produ

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1-Deoxy-,-Xylulose 5-Phosphate Synthase (DXS), a Crucial Enzyme for Isoprenoids Biosynthesis, the monomer and the dimer as compared to the other enzymes. The active site of DXS is located at the interface of domains I and II in the same monomer. The coenzyme TPP is mostly buried in the complex, but the C2 atom of its thiazolium ring is exposed to a solvent-accessible tunnel that is likely t

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Microbially Derived Semisynthetic Artemisinin,on of the mevalonate pathway, produced 150 mg/L of amorpha-4,11-diene. The cDNAs encoding the cytochrome P450 that oxidizes amorpha-4,11-diene to artemisinic acid, ., and its cognate reductase were isolated from . and expressed in amorpha-4,11-diene-producing . and yeast, leading to the production o

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Artemisinin: Controlling Its Production in ,,inin production, but the response was less definitive. Glucose also increased expression of some of the genes in the artemisinin biosynthetic pathway, thereby suggesting that this sugar is acting not only as a carbon source but also as a signal. As we develop a better understanding of the regulation