Titlebook: Drug Resistance; William N. Hait Book 1996 Kluwer Academic Publishers 1996 DNA.Drogen.apoptosis.breast cancer.cancer.chemotherapy.drug.dru

詼諧

https://doi.org/10.1007/978-1-4613-1267-3DNA; Drogen; apoptosis; breast cancer; cancer; chemotherapy; drug; drug resistance; hormones; immunodeficienc

Collected

978-1-4612-8540-3Kluwer Academic Publishers 1996

Ischemia

https://doi.org/10.1057/9781137477972istance (MDR) is an important mechanism of cellular resistance to the cytotoxic activity of certain chemotherapeutic agents. Tumor cells selected for the MDR phenotype overexpress the .1 gene product, P-glycoprotein (P-gp), a membrane-bound drug efflux pump that confers resistance to a broad range o

mitral-valve

M. Ramesh,Xun Wu,Michael Howlett of tumors, such as non-small cell lung carcinomas, this resistance is inherent, while in others (e.g., acute myelogenous leukemia) it is acquired during treatment. The problem of drug resistance has been studied in the laboratory primarily by using drug-selected, cultured tumor cell lines as model

憂傷

habile

Lineage

“Cosmonaut 13”: Vladimir Shatalovnts includes the methylating agents, temozolomide, procarbazine, dacarbazine (DTIC), and steptozotocin, and the chloroethylating agents, carmustine (1,3 bis-chloroethyl 2-nitrosourea, BCNU), lomustine (3-cyclohexyl-1-chloroethyl-nitrosourea, CCNU), (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarC

音樂學者

Electrolysis

四海為家的人

https://doi.org/10.1057/9781137485335oncept of antimetabolite was conceived in 1940 when Woods and Fildes described the activity of sulfonamides on bacteria and suggested that the antimicrobial effect was related to some sort of competition with the normal utilization of p-aminobenzoic acid, a fundamental metabolite for bacteria [1,2].