Titlebook: Ion Channels as Targets in Drug Discovery; Gary Stephens,Edward Stevens Book 2024 The Editor(s) (if applicable) and The Author(s), under e

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Conservation of Ligand Binding Between Voltage-Gated Sodium and T-Type Calcium Channels,Na.1) and calcium (Ca.3) channels. When the cell membrane is moderately depolarized, these channels allow the rapid influx of their respective ions – Na. and Ca.. Na.1 and Ca.3 channels are structurally related, and their expression overlaps in various excitable tissues, such as muscles and neurons.

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Voltage-Gated Sodium Channels as Drug Targets in Epilepsy-Related Sodium Channelopathies,ts in the genes encoding the brain-expressed VGSCs have been identified in patients with severe epilepsy syndromes making clear that proper VGSC activity is required for normal neurological development and function. Given this central role in determining neuronal physiology, VGSCs are one of the mos

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The Contribution of Genetic Sequencing Information to the Identification and Functional Characterize mutation causes the disease (monogenic diseases) and where the mutation is more subtly associated with the disease and changes the likelihood of a patient developing the disease (polygenic diseases)..In this review, we describe examples of monogenic diseases where both gain and loss of channel fun

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The Voltage-Gated Potassium Channel Kv2.1 as a Multicellular Drug Target,rofiles makes them interesting drug targets. The K.2.1 channel, encoded by the . gene, has a multitude of physiological roles from setting neuronal firing frequency to influencing viral replication. Here we look at the biophysical fingerprint of the K.2.1 channel and its role in a variety of unique

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Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Targeted Therapeutics for Cystic Fibrosiuse of the disease, pathogenic variants in the ATP-binding cassette transporter cystic fibrosis transmembrane conductance regulator (CFTR). Here, we selectively review understanding of CFTR function as an ATP-gated anion channel, its physiological role in epithelia and the molecular mechanisms of CF

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Validation of TMEM16A Modulation as a Therapeutic Approach for the Treatment of Cystic Fibrosis: Thulation of these channels as a therapeutic approach for the treatment of muco-obstructive respiratory diseases, including cystic fibrosis. However, the recent literature is paradoxical with some investigators suggesting that inhibition of TMEM16A is the correct approach, while others advocate increa

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Targeting Acid-Sensing Ion Channels in Disease,-sensing ion channels (ASICs) are exquisitely sensitive to decreases in pH and activated by protons. The expression and function of ASICs is enhanced under conditions of ischemia, inflammation, and trauma. Here, we will focus on this family of ion channels whose main role appears to be the detection