Titlebook: Introduction to Proteomics; Tools for the New Bi Daniel C. Liebler Book 2002 Springer Science+Business Media New York 2002 Proteomics.prote

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Book 2002bles protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression,characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

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Overview of Analytical Proteomicsed in Chapter 2). If one can obtain sequences of several peptides that map to the same gene product, this strengthens the validity of the match. Accordingly, the essence of analytical proteomics is to convert proteins to peptides, obtain sequences of the peptides, and then identify the corresponding proteins from matching sequences in a database.

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Protein Expression Profilingtrying to identify novel targets for therapeutic drugs. Perhaps the ultimate challenge of proteomics is to measure the status of all cellular proteins as they change with time. Unfortunately, the technology is not yet there. Nevertheless, the problem of comparing proteomes between two states of a cell or organism is relevant and important.

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Proteomics and the New Biology in the early 1990s and mirror the terms “genomics” and “genome,” which describe the entire collection of genes in an organism. These “-omics” terms symbolize a redefinition of how we think about biology and the workings of living systems (.). Until the mid-1990s, biochemists, molecular biologists,

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