Titlebook: Intelligent Strategies for Pathway Mining; Model and Pattern Id Qingfeng Chen,Baoshan Chen,Chengqi Zhang Book 2014 Springer International P

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Detecting Inconsistency in Biological Molecular Databases Using Ontologies,screpancies in nomenclature, various schemas and incompatible formats of biological databases, however, result in a significant lack of interoperability among databases. Therefore, data preparation is a key prerequisite for biological database mining. Integrating diverse biological molecular databas

Dorsal

Exploration of Positive Frequent Patterns for AMP-Activated Protein Kinase Regulation,pply. An investigation into the degree of activation and deactivation of AMPK subunits under exercise can provide valuable data for understanding AMPK. In particular, the effect of AMPK on muscle cellular energy status makes this protein a promising pharmacological target for disease treatment. As m

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Mining Protein Kinase Regulation Using Graphical Models, characteristics of protein kinase regulation by studying the activation and inhibition of kinase subunits in response to varied stimuli. Bayesian network (BN) is a formalism for probabilistic reasoning that has been widely used for learning dependency models. However, for high-dimensional discrete

Tempor

Mining Inhibition Pathways for Protein Kinases on Skeletal Muscle,nto the degree of activation and inhibition of catalytic and regulatory subunits of protein kinases, assists in understanding their profound effect on a cell. Especially, the inhibitors of kinase activity are a frequent cause of diseases, where kinases participate many aspects that control cell grow

Graves’-disease

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Interval Based Similarity for Function Classification of RNA Pseudoknots,oded by biological sequences is important to acquire knowledge of their biochemical functions in varied pathways but remains a fundamental challenge. Recent interest in RNA regulation has resulted in a rapid growth of deposited RNA secondary structures in varied databases. However, a functional clas

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Discovery of Structural and Functional Features Bind to RNA Pseudoknots,ized that there is an abundance of functional structures with frameshifting, regulation of translation, and splicing functions. However, the inherent signal for secondary structures is weak and generally not straightforward due to complex interleaving substrings. This makes it difficult to explore t

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Mining Featured Patterns of MiRNA Interaction Based on Sequence and Structure Similarity,pathways. There are many literatures focusing on predicting miRNA target and exploring gene regulation network of miRNA family. We suggest, however, the study to identify the interaction between miRNAs is insufficient. This chapter presents a framework to identify relationships of miRNAs using joint