Titlebook: Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System; Mohan K. Raizada,M. Ian Phillips,Derek LeRoith Bo

會(huì)議

Evolution of Insulin and Insulin Receptorsay be extrapancreatic sources of insulin and that insulin may act on tissues other than its classic target tissues. Of specific interest to us has been the suggestion that nervous tissue may be an extrapancreatic source of insulin synthesis and, furthermore, that nervous tissue may be a specific tar

出汗

Evidence for Central Nervous System Insulin Synthesis, two basic questions have remained unanswered. The first is the source of this insulin within the CNS, whether locally produced or of pancreatic origin. Second is the function of insulin within the CNS. Does insulin have similar effects. centrally to those outside the CNS or does insulin have uniqu

打火石

Localization of Insulin to Neuronal Cellscribed in the central nervous system., the exact origin of the peptide remains unclear. A local (i.e. central nervous system) origin for the peptide has been suggested by some groups of investigators., while others contend that insulin enters the brain from the blood vascular system .. For example,

Neutral-Spine

Synthesis of Insulin or a Similar Peptide in the Pituitary Gland and in Retinal Muller Cellsoith, et al., 1980, 1981, 1983; Falkner, et al., 1975; Meneses and Oritz, 1975; Duve and Thorpe, 1979; Yuri, et al., 1980)., Similar reports have appeared claiming localization and possible synthesis of insulin in the extrapancreatic tissues of vertebrates (Hendricks, et al.,1983). Proposed extrapan

Vertical

Insulin in the Central Nervous System: A Regulator of Appetite and Body Weightquences of these actions at the level of the organism have not been defined. In this chapter we advance the hypothesis that insulin may act as a regulator of body weight. In 1979, Woods and Porte suggested that insulin levels in the cerebrospinal fluid (CSF) may act as an indicator of body adiposity

elastic

Insulin in the Brain: A Feedback Loop Involving Brain Insulin and Circumventricular Organsd not influence the brain. The independence of the central nervous system (CNS) from peripheral insulin has always had a certain teleological logic to it. The brain, being so important physiologically, must be preserved from having to require insulin to control its glucose metabolism. Since insulin

特征

Structural Evidence for a Subtype of Insulin Receptor in the Central Nervous Systemcal role of insulin in the central nervous system (CNS). One area of CNS physiology affected by insulin is the regulation of feeding behavior and body weight. Chronic intracerebral ventricular infusion of insulin reduces food intake and body weight., suggesting that insulin acts as a satiety factor

moribund

Physiologically Unique Insulin Receptors on Neuronal Cellsnal insulin receptors. Kinetic characteristics of .I-insulin binding to neuronal cells were similar to those for glial and peripheral cells although the a and . subunits of the neuronal receptor were significantly smaller in size. Insulin inhibited [.H]norepinephrine uptake and stimulated [.H]-serot

Shuttle

Insulin Receptors in Brain Development see Hendricks et al., 1983). Since then, insulin or insulin-like material has been detected in numerous species, both vertebrate and invertebrate, as well as in bacteria and fungi (LeRoith et al., 1980; LeRoith et al., 1981). Accordingly, this has prompted the search in these tissues and cells for

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