Titlebook: Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System; Mohan K. Raizada,M. Ian Phillips,Derek LeRoith Bo

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Costume

Role of Protein Phosphorylation in Growth Factor Signal Transductiongical conditions including diabetes. In this paper, which consists primarily of a review of work carried out here and elsewhere, a role for protein phosphorylation in the mediation of many of the metabolic responses of cells to growth factors is examined.

Texture

Glucose Transporters: Overview and Implications for the Brainrthermore, we will examine the role of the glucose transport effector system in pathophysiologic insulin-resistant states and modifications which prevent the insulin response in insulin insensitive tissues such as liver and brain.

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Structural Evidence for a Subtype of Insulin Receptor in the Central Nervous Systemin the CNS. Consistent with this notion is the report that Zucker rats carrying the fa gene have fewer brain insulin receptors.. Furthermore, insulin has been shown to directly alter the firing rate of glucose-sensitive neurons in the ventromedial and lateral hypothalamus..

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