Titlebook: Insulin Action; Ashok K. Srivastava,Barry I. Posner Book 1998 Springer Science+Business Media Dordrecht 1998 ATP.Glycogen.protein.receptor

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Betty Lamothe,Bertrand Duvillié,Nathalie Cordonnier,Anne Baudry,Susan Saint-Just,Danielle Bucchini,Jystems; however, its application to the inner ear is especially challenging. Access to the membranous cochlea is hampered by the bony labyrinth, and the membranous labyrinth itself offers its own technical challenges due to tissue sparsity and difficulty in dissociating and isolating individual cell

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Pascal Peraldi,Bruce Spiegelmanogies, and in reconstructing normal hearing. Auditory peripheral properties cannot be investigated in humans at the level of detail possible in experimental animals and is therefore largely modeled on detailed knowledge obtained from such animals. However, the auditory periphery shows significant di

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The IRS-signalling system: A network of docking proteins that mediate insulin action,factors and cytokines, including insulin. Insulin action is initiated through the insulin receptor, a transmembrane glycoprotein with intrinsic protein tyrosine kinase activity. The tyrosine kinase mediates the insulin response through tyrosine phosphorylation of various cellular substrates, in part

SHOCK

Role of binding proteins to IRS-1 in insulin signalling,nases. The activated insulin receptor phosphorylates the intracellular substrate IRS-1, which then binds various signalling molecules that contain SRC homology 2 domains, thereby propagating the insulin signal. Among these IRS-1-binding proteins, the Grb2-Sos complex and the protein tyrosine Phospha

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Insulin regulation of the Ras activation/inactivation cycle,ic responses are mediated by signals through the small molecular weight guanine nucleotide binding protein, Ras. In the last decade, great progress has been made in understanding the molecular mechanisms which regulate the insulin mediated conversion of Ras from its inactive, GDP-bound state, to the

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Insulin signal transduction through protein kinase cascades,gnalling intermediates, and their status as participants in insulin regulation of energy metabolism. Best characterized is the Ras-MAPK pathway, whose input is crucial to cell fate decisions, but relatively dispensable in metabolic regulation. By contrast the effectors downstream of PI-3 kinase, alt

VEIL

Esophagitis

Insulin receptor internalization and signalling,tissues. Insulin binding to its cell surface receptor is rapidly followed by internalization of insulin-IRK complexes into the endosomal apparatus (EN) of the cell. Internalization of insulin into target organs, especially liver, is implicated in effecting insulin clearance from the circulation. Int

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Spatial determinants of specificity in insulin action, remains largely unknown. This review focuses on the role compartmentalization plays in insulin action, both in signal initiation and in signal reception. Two examples are discussed: (1) a novel signalling pathway leading to the phosphorylation of the caveolar coat protein caveolin, and (2) a recent