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Titlebook: Innovations for Next-Generation Antibody-Drug Conjugates; Marc Damelin Book 2018 Springer International Publishing AG, part of Springer Na

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發(fā)表于 2025-3-21 16:58:37 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Innovations for Next-Generation Antibody-Drug Conjugates
編輯Marc Damelin
視頻videohttp://file.papertrans.cn/468/467020/467020.mp4
概述Focus on next-generation ADCs for oncology and other diseases.Description & analysis of current technological innovations for ADCs.ADC clinical development in the context of immuno-oncology
叢書名稱Cancer Drug Discovery and Development
圖書封面Titlebook: Innovations for Next-Generation Antibody-Drug Conjugates; Marc Damelin Book 2018 Springer International Publishing AG, part of Springer Na
描述. .Antibody-drug conjugates (ADCs) stand at the verge of a transformation.? Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges.? This volume focuses on the next generation of ADCs and the innovations that will enable them.? The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies.? While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases.. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties.? However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing.? The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies.? These innovations will inspire and educate scientists who are designing next-generation ADCs
出版日期Book 2018
關鍵詞Antibody-Drug Conjugates; pharmacokinetics,; oncology; immuno-oncology; Conjugation
版次1
doihttps://doi.org/10.1007/978-3-319-78154-9
isbn_softcover978-3-030-08627-5
isbn_ebook978-3-319-78154-9Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightSpringer International Publishing AG, part of Springer Nature 2018
The information of publication is updating

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Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/i/image/467020.jpg
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Innovations for Next-Generation Antibody-Drug Conjugates978-3-319-78154-9Series ISSN 2196-9906 Series E-ISSN 2196-9914
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?These conditions can lead to neck pain and/or neurological deficit that can significantly compromise an individual’s quality of life. ?Despite the regularity of these conditions, there remains both uncertainty and controversy regarding optimal management. ?No standard of care exists, however there
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Marc Damelinrovide practical applications of the chapters key points.WriDegenerative disorders of the cervical spine are among the more common reasons why patients seek medical attention or consult with a spine specialist. ?These conditions can lead to neck pain and/or neurological deficit that can significantl
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Aman P. Singh,Dhaval K. Shahesearch, held in Alicante, Spain. The success of this first meeting led to the second held, two years later in Sendai, Japan, organized as a satellite of the VII ISER. We were fortunate that these meetings began at a time of vigorous research activity in the area of retinal degenerations, thanks to
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Elizabeth VanAlphen,Omar Perezsst in welcher Situation die besten Behandlungsergebnisse er.Der Weg zur richtigen Therapieentscheidung in der HWS-Chirurgie. Zur Behandlung degenerativer Erkrankungen der Halswirbels?ule hat sich eine Vielzahl unterschiedlicher Verfahren mit spezifischen Indikationen, Vor- und Nachteilen entwickelt
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